GHRP-6 is not an active fragment of growth hormone releasing hormone (GHRH). Which means it stimulates the body’s own secretion of HGH. Human Growth hormone has been shown in studies to promote lean body mass and reduce adiposity (fat). This growth hormone releasing peptide is distinct from GHRH and do not act at the GHRH receptor, but instead acts at the growth hormone secretagogue receptor, now renamed as the gh-relin receptor.
GHRP-6’s special sequence is considered to provide a signal to the body to begin secreting Growth Hormone(GH) release while also blocking Somatostatin, a hormone that inhibits Growth Hormone release. Research studies have shown that GHRP-6 stimulation of Growth Hormone has host of beneficial effects such as decreased body fat, increased muscle, and increased strength and stamina so maximizing the production and secretion can be a great addition to improved animal physical shape. Increased amounts of Growth Hormone then can cause the liver to secrete the hormone IGF-1 which has also been implicated in improving the animal body’s ability to burn fat and build muscle. Clinical cases have shown that the use of GHRP-6 was associated with increased muscle mass and a reduction of body fat. GHRP-6 has been one of the most thoroughly studied and is believed to be acting naturally on both pituitary and hypothalamic sites (Fairhall et al. 1995). This has been demonstrated in the primary pituitary cells of rats in a time-dependent and dose-dependent manner. In another study of Fairhall et al. (1995), they concluded that the major target of the GHRP-6 in vivo is the hypothalamus after observing that the GH( Growth Hormone) release induced by the central GHRP-6 administration in guinea pigs was inhibited by the central action of somatostatin. Furthermore, an inhibition by somatostatin with the activated GRF neurons ( GRF=Growth Hormone Releasing Factor), induced by GHRP-6, was observed via receptors known to be located on or near the GRF themselves. However, it was also observed that GHRP-6 had no effect on the intracellular cAMP levels unlike that of GHRP-2. This particular experiment further indicated that GHRP-6 is effectively stimulating GH release from somatotrophs through different receptors, the mechanisms of which are not yet known (Chan et al. 1989).
However, some researchers suggest that action and efficiency of growth hormone is dependent on the physical condition of the experimental unit. In humans for example, GH secretion decreases with obesity. This is contrary in the case of the GHRP-6 which showed increased (almost twice that of GHRP) GH responses when administered in obese patients (Cordido et al. 1993). Though obesity has shown affecting the efficiency of the hormone, it was also suggested that GHRP-6’s effects, at least at the dose-dependent manners, were found to be sex- and age-independent without being affected by the noadregenic pathways using the a2 adrenergic receptors (Penalva et al. 2008).
Recommended dosage of GHRP-6 :
• 0.10mg once per day for anti-aging.
• Between 0.40-0.60mg, divided in two or three doses per day for muscle gain and fat loss, directed via subcutaneous injections. Optimal times for injection are: first thing in the morning, pre or post workout and at night before bed.
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